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一些水溶性很小的药物,通过与水溶性载体形成分散体,可以提高其溶解度。卵清蛋白(分子量45000)是一种水溶性很好的无害的天然蛋白质,所以较化学合成的物质更有它的优点。材料、药品:卵清蛋白、氟联苯丙酸、双氯高灭酸、吲哚心安、地尔硫(?)。样品制备:取药物和卵清蛋白(按1:1,1:5,1:10,w/w)放入研钵,用1.4倍水研磨1h,然后在25℃真空干燥48h。测定内容与方法:溶解作用和溶解度、差示扫描量热法(DSC)和X 射线衍射法。结果和讨论:由于卵清蛋白的作用,药粉
Some very water-soluble drugs, by forming a dispersion with a water-soluble carrier, can increase its solubility. Ovalbumin (molecular weight 45000) is a harmless natural protein with good water solubility, so it has more advantages than chemically synthesized materials. Materials and Drugs: Ovalbumin, Fiprofen, Diclofenac, Indoxetine, Diltiazem (?). Sample Preparation: The drug and ovalbumin (1: 1, 1: 5, 1: 10, w / w) were placed in a mortar and ground with 1.4 times water for 1 hour and then dried under vacuum at 25 ° C for 48 hours. Determination of content and methods: dissolution and solubility, differential scanning calorimetry (DSC) and X-ray diffraction. Results and Discussion: Due to ovalbumin action, powder