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目的探讨自制含漱液对同期放化疗鼻咽癌患者口腔黏膜炎的影响。方法 66例同期放化疗鼻咽癌患者随机分为对照组(35例)和实验组(31例)。实验组预防性予自制含漱液(苯海拉明+利多卡因+生理盐水)含漱;对照组用生理盐水含漱。口腔黏膜炎的诊断参考RTOG毒性反应标准。结果放疗至30Gy时,实验组14例发生口腔黏膜炎,2例为重度黏膜炎,对照组24例口腔黏膜炎,5例为重度黏膜炎(P=0.137)。剂量>30Gy至放疗结束时,实验组22例口腔黏膜炎,6例为重度黏膜炎,对照组32例口腔黏膜炎,18例为重度黏膜炎(P=0.012)。结论自制含漱液可用于防治放疗后发生放射性口腔黏膜炎,降低发生率,减轻黏膜炎严重程度。
Objective To investigate the effect of self-made gargle solution on oral mucositis in patients with nasopharyngeal carcinoma treated with concurrent radiotherapy and chemotherapy. Methods Sixty-six patients with nasopharyngeal carcinoma received concurrent radiochemotherapy were randomly divided into control group (35 cases) and experimental group (31 cases). In the experimental group, the self-prepared sputum (benzhydramine + lidocaine + normal saline) contained antimony in the preventive group; the control group contained antimony in normal saline. The diagnosis of oral mucositis refers to the RTOG toxic reaction standard. Results After radiotherapy to 30 Gy, 14 cases of oral mucositis occurred in the experimental group, 2 cases of severe mucositis, 24 cases of oral mucositis in the control group, and 5 cases of severe mucositis (P=0.137). At doses >30 Gy until the end of radiotherapy, 22 cases of oral mucositis were observed in the experimental group, 6 cases were severe mucositis, 32 cases of oral mucositis in the control group, and 18 cases of severe mucositis (P=0.012). Conclusion Self-made gargle can be used to prevent the occurrence of radioactive oral mucositis after radiotherapy, reduce the incidence, and reduce the severity of mucositis.