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目的：间接致突变物需经代谢活化才具有致突变作用。彗星试验检测间接致突变物的ＤＮＡ损伤作用时，应采用的体外活化条件未见系统报导。本试验旨在对此做有益探索。方法：以两种已知间接致突变物苯并（α）芘和２－氨基芴为受试物，用彗星试验检测了不同活化方式（混合法和预?
Objective: Indirect mutagens need to be metabolically activated to have a mutagenic effect. Comet assay to detect DNA damage caused by indirect mutagenesis, the activation conditions should not be used in vitro reported in the system. The purpose of this experiment is to do a useful exploration. Methods: Two kinds of known indirect mutagenic benzo (α) pyrene and 2-aminofluorene were used as test materials, and different activation methods (mixed method and pretreatment method)