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测定了不同月龄大鼠血小板聚集率、花生四烯酸诱导的血小板ＴｘＢ２和动脉组织６－酮－ＰＧＦ１α、ＴｘＢ２含量以及动脉前列环素样活性，并与青年大鼠比较。结果表明，老龄大鼠血小板聚集率（７１．１±１４．７％）明显高于青年组（４４．３±１４．４％）（Ｐ＜０．０１），血小板ＴｘＢ２水平（１１５．９±４５．９ｎｇ／３×１０８血小板）增高（Ｐ＜０．０５），而动脉组织中６－酮－ＰＧＦ１α（２２１．１±１１２．７ｐｇ／ｍｇ）和前列环素样活性（５７．１±２２．９％）显著降低（Ｐ＜０．０１），动脉的ＴｘＢ２水平（２３３．６±６４．０ｐｇ／ｍｇ干重血小板）无明显改变（Ｐ＞０．０５）。提示老龄大鼠血小板花生四烯酸代谢增强和动脉组织花生四烯酸代谢降低以及动脉抑制血小板聚集的活性低下，这些改变可能是血小板功能随增龄而增强的主要机制之一。
The platelet aggregation rate, the aromatase-induced platelet TxB2 and 6-keto-PGF1α, TxB2 content in rat arterial tissue and the arterial prostacyclin-like activity were measured and compared with those in young rats. The results showed that the platelet aggregation rate (71.1 ± 14.7%) in aged rats was significantly higher than that in youth group (44.3 ± 14.4%) (P <0.01). The platelet TxB2 level (115.9 ± 45.9ng / 3 × 108 platelets) (P <0.05), while the arterial tissue 6-keto-PGF1α (221.1 ± 112.7pg / mg) and prostacyclin-like activity .9%) (P <0.01). There was no significant change in arterial TxB2 level (233.6 ± 64.0pg / mg dry weight platelet) (P> 0.05). These results suggest that increased metabolism of arachidonic acid and decreased arachidonic acid metabolism in the aorta rat platelets and arterial inhibition of platelet aggregation activity may be one of the main mechanisms of platelet function enhancement with age.