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Barrett食管指食管正常复层麟状上皮被化生的柱状上皮所替代,可并发于10％～12％慢性胃食管返流的病人中,并可诱发食管腺癌和胃癌。在70及80年代其发生率迅速增加,现已成为美国15种最常见的癌症之一。由于其被检出时大多已属晚期,93％病人最终将死于此癌。由Barrett食管发展成癌需经多个步骤的演变过程:由Barrett特殊型化生经轻度和重度异型增生、早期腺癌,最终发展成浸润转移性癌。但在随访3～5年内仅发现一部分病人的病变进展。因此,更
The Barrett’s esophagus is a replacement of the normal layered epithelium with a metaplastic columnar epithelium. It can develop concurrently in 10% to 12% of patients with chronic gastroesophageal reflux and can induce esophageal adenocarcinoma and gastric cancer. Its incidence increased rapidly in the 70s and 80s, and it has now become one of the 15 most common cancers in the United States. Since most of them were already detected at the late stage, 93% of patients eventually died of this cancer. The development of cancer from the Barrett’s esophagus requires a multi-step evolution: the development of mild and severe dysplasia, early adenocarcinoma, and the development of invasive metastatic carcinomas by Barrett’s specialization. However, in only 3 to 5 years of follow-up, only a part of the patient’s progress was found. Therefore, more