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目的 :探讨鼻咽血管纤维瘤与体内性激素的临床关系。方法 :采集 2 4例鼻咽血管纤维瘤患者手术前后外周静脉血标本 (术前 2 4例 ,术后 2 0例 )及 2 4例健康男性青年作为对照组 ,用放射免疫测定法分别检测鼻咽血管纤维瘤患者手术前后及对照组血清性激素水平。结果 :①鼻咽血管纤维瘤患者手术前后血清性激素水平变化不大 (P >0 .0 5 ) ;②血清雌二醇、孕酮术前水平较正常对照组低 (P <0 .0 5 ) ,血清睾酮术前水平与正常对照组水平变化不大(P >0 .0 5 ) ;③鼻咽血管纤维瘤患者术后性激素水平与正常对照组水平变化不大 (P >0 .0 5 )。结论 :鼻咽血管纤维瘤发病机制与体内性激素水平可能存在一定程度的相关关系。
Objective: To investigate the clinical relationship between nasopharyngeal angiofibroma and sex hormones in vivo. Methods: Peripheral venous blood samples (24 cases before operation and 20 cases after operation) and 24 healthy male youths were collected from 24 patients with nasopharyngeal angiofibroma as control group. Radioimmunoassay was used to detect nasal Serum sex hormone levels in patients with pharyngeal angiofibroma before and after operation and in control group. Results: ① The levels of serum sex hormone did not change much before and after operation in patients with nasopharyngeal angiofibroma (P> 0.05); ② The levels of serum estradiol and progesterone before operation were lower than those in normal control group (P <0.05) (P 0. 05). ③The level of sex hormones in nasopharyngeal angiofibroma patients did not change much compared with the control group (P> 0.05) . Conclusion: The pathogenesis of nasopharyngeal angiofibroma may have a certain degree of correlation with the level of sex hormone in the body.