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为探讨结直肠癌P5 3蛋白异常表达的危险因素 ,对12 1例原发性结直肠癌病人手术切除癌组织进行S -P免疫组化检测 ,将病例划分为P5 3异常表达阳性组和阴性组 ,应用病例 -病例研究方法及SAS软件进行因素分析。结果表明 ,P5 3异常表达阳性组病人 72例 ,阳性率 5 9 5 0 % ;单因素分析 ,有 5个因素与P5 3异常表达有联系 ,它们是吸烟 (0R =2 0 95 )、接触毒物 (OR =2 180 )、家人吸烟 (OR =3 0 96 )、自感生活压抑(OR =2 30 0 )、食醋 (0R =0 80 0 ) ;多因素非条件Logistic回归分析 (a =0 0 5 ) ,有家人吸烟、食醋 2个因素引入模型 ,OR(95 %CI)分别为 3 46 7(1 5 19,7 915 )和 0 774(0 6 2 2 ,0 96 4) ;按男女分层进行多因素分析 (α =0 0 5 ) ,男性的吸烟被引入模型 ,OR =5 338(1 476 ,19 30 1) ;女性的家人吸烟被引入模型 ,OR =6 5 6 4(1 5 0 1,2 8 6 97)。结果提示吸烟及食醋两个因素与结直肠癌P5 3异常表达有关
In order to investigate the risk factors for the abnormal expression of P53 protein in colorectal cancer, S-P immunohistochemistry was performed on 121 cases of primary colorectal cancer. S-P immunohistochemistry was used to classify the cases as positive and negative for P53 abnormal expression. Group, application case-case study method and SAS software for factor analysis. The results showed that 72 patients with abnormal expression of P53 were positive and the positive rate was 595.5%. There were 5 factors associated with abnormal expression of P53 in the univariate analysis. They were smoking (0R = 2095) and exposure to toxicants. (OR = 2 180), family smoking (OR = 3 0 96), self-inhibition (OR = 2 30 0), vinegar (0R = 0 80 0); multivariate unconditional Logistic regression analysis (a =0) 0 5 ), there are two factors of family smoking and vinegar introduction model, OR (95% CI) were 3 46 7 (1 5 19, 7 915) and 0 774 (0 6 2 2 ,0 96 4) respectively; Male and female stratified for multivariate analysis (α = 0 05), male smoking was introduced into the model, OR = 5 338 (1 476, 19 30 1); female family smoking was introduced into the model, OR = 6 5 6 4 ( 1 5 0 1,2 8 6 97). The results suggest that smoking and vinegar are associated with abnormal expression of colorectal cancer P53