,Fatal graft versus host hemolytic reaction from Rhesus compatible mismatched liver transplantation

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Matching for Rhesus (Rh) blood group is not part of organ allocation systems. The principle conce expressed in the literature is that Rh-negative recipients might become sensitized and produce anti-D antibody which would have consequences for them if transfusion with Rh-positive blood or a pregnancy were to occur later. While Rh allosensitization is thought to occur in over 80%of Rh-negative recipients of Rh-positive blood, Starzl reported that it is less much less common in organ (liver, heart, lung) recipients even if they received Rh-positive blood during the operation (1). A more recent review of pediatric liver transplantation confirms the very low rate of allosensitization of Rh recipients of grafts from Rh-positive donors (2). In theory, there should be no risk of rejection if the combination is reversed—Rh-negative donor to a Rh-positive recipient. Therefore, it does not appear to be necessary to consider Rh status when allocating organs for transplantation.
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