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目的 探讨慢性泪囊炎致病菌分布及药物敏感性,为临床制定合理用药方案提供科学依据.方法 回顾性分析2013年12月-2015年12月信阳市眼科医院眼科收治的120例慢性泪囊炎患者的临床资料,泪囊分泌物取样,培养鉴定病原菌,做药物敏感试验,观察致病菌的种类、检出率及对药物敏感情况.结果 在送检标本120例中,均检出一种致病菌,致病菌菌株阳性101例,检出率84.2％.18例革兰阴性杆菌患者中,对氯霉素、左氧氟沙星、庆大霉素、妥布霉素、头孢唑啉、舒巴坦/头孢哌酮的敏感率较高,分别占88.9％、94.4％、83.3％、94.4％、77.8％、94.4％;74例革兰阳性球菌患者中,对利福平、氯霉素、左氧氟沙星、庆大霉素、妥布霉素、头孢唑啉、舒巴坦/头孢哌酮的敏感率较高,分别占64.9％、52.7％、83.8％、87.8％、86.5％、77.0％、98.6％.结论 慢性泪囊炎的致病菌较多,以革兰阳性球菌、革兰阴性杆菌为主,可首选氯霉素、左氧氟沙星、庆大霉素、妥布霉素、头孢唑啉、舒巴坦/头孢哌酮等药物.“,”Objective To investigate the chronic dacryocystitis pathogens distribution and drug sensitivity for the clinical development of rational drug use program provides a scientific basis.Methods A retrospective analysis of December 2013-December 2015 clinical data of 120 patients admitted to ophthalmology patients with chronic dacryocystitis,lacrimal secretions sampling,culture and identification of pathogens,do drug susceptibility testing,obsewation pathogens species,the detection rate and drug-sensitive cases.Results In the submission of samples in 120 cases,were detected in one kind of bacteria,pathogenic strains of positive 101 cases,the detection rate of 84.2％.18 cases of patients with Gram-negative bacteria,chloramphenicol,levofloxacin,gentamicin,tobramycin,cefazolin,sulbactam/cefoperazone sensitivity rates higher,accounting for 88.9％,94.4％,83.3％,94.4％,77.8％,94.4％;74 cases of patients with Gram -positive cocci,rifampin,chloramphenicol,levofloxacin,gentamicin,tobramycin,cefazolin,SBT/cefoperazone sensitivity rates higher,accounting for 64.9％,respectively,52.7％,83.8％,87.8％,86.5％,77.0％,98.6％.Conclusion Chronic dacryocystitis many pathogens,Gram-positive cocci,gram-negative bacilli,may be the preferred chloramphenicol,levofloxacin,gentamicin,tobramycin,cefazolin,Shuba Tan/cefoperazone and other drugs.