本文用电生理技术，在离体豚鼠左房对氟卡尼电生理特性进行了研究。氟卡尼能剂量和频率依赖性地抑制动作电位零相最大上升速率（Ｖｍａｘ），动作电位幅度（ＡＰＭ）和超射（ＯＳ）。研究发现氟卡尼在较高频率刺激下（２Ｈｚ，３．３Ｈｚ）趋向于延长动作电位时程，具有时间和频率依赖性。这对缺血和再灌注诱发的心律失常具有重要意义。在不同频率刺激下，氟卡尼能使被缩短的动作电位时程趋向于正常并具频率依赖性。这些可能与其治疗房性心律失常有关。 In this paper, electrophysiological techniques were used to study the electrophysiological properties of flecainide in isolated left atrium of guinea pigs. Flecarnide dose and frequency-dependent inhibition of action potential maximum rate of zero-phase rise rate (Vmax), action potential amplitude (APM) and hyperacute (OS). Study found that flecainide at higher frequency stimulation (2Hz, 3.3Hz) tend to extend the action potential duration, with time and frequency-dependent. This is important for ischemia and reperfusion induced arrhythmias. Flecainide tended to be normal and frequency-dependent in the shortened duration of action potentials at different frequencies. These may be related to its treatment of atrial arrhythmias.