中枢性抗高血压药通过抑制延脑交感活性、减慢心率、减少外周阻力、降低血浆肾素活性,从而达到降压治疗目的。第一代中枢性抗高血压药如α-甲基多巴、可乐宁(α_2-受体激动剂)等,常伴有口干、嗜睡、疲乏等副作用,不利于长期用药。而第二代中枢性抗高血压药如Rilmenidine和Moxonidine.作为 Central antihypertensive drugs by inhibiting the sympathetic activity of the brain, slow down the heart rate, reduce peripheral resistance, reduce plasma renin activity, so as to achieve the purpose of antihypertensive treatment. The first generation of central antihypertensive drugs such as α-methyl dopa, clonidine (α 2 -receptor agonist), often accompanied by dry mouth, lethargy, fatigue and other side effects, is not conducive to long-term medication. The second generation of central antihypertensives such as Rilmenidine and Moxonidine