从三个方面重点阐述了血管紧张素II对细胞因子网络的调节作用 :①对致纤维化细胞因子的调节 ,诱导血管平滑肌、间质纤维母细胞等血小板源生长因子的表达 ;②对前炎性细胞因子的影响 ;促进白细胞介素 6的分泌、抑制白细胞介素 1 2分泌 ,促进单核细胞趋化蛋白的表达 ;③对其他生长因子的影响 ,如抑制肝细胞生长因子的表达 ,上调血管内皮生长因子的表达。 From three aspects, the regulation of angiotensin II on the cytokines network is mainly described: (1) the regulation of induced fibroblasts induces the expression of platelet-derived growth factors such as vascular smooth muscle and interstitial fibroblasts; (2) Promote the secretion of IL-6, inhibit the secretion of IL-12, and promote the expression of monocyte chemoattractant protein; ③ the impact on other growth factors, such as inhibiting the expression of hepatocyte growth factor Vascular endothelial growth factor expression.