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为探讨咳嗽变异性哮喘(CVA)发病机理,本文采用病例对照方法,对32例临床诊断CVA患儿进行外周血T淋巴细胞亚群和血清免疫球蛋白测定。结果表明,观察组CD3、CD8明显降低,CD4/CD8比值升高,血清IgE明显增高,与对照组比较差异非常显著(P<0.01)。提示CVA患儿存在着免疫功能紊乱,其发病机理可能与支气管哮喘相同。
In order to investigate the pathogenesis of CVA, we use the case-control method to measure the T-lymphocyte subsets and serum immunoglobulins in 32 cases of clinically diagnosed CVA. The results showed that the levels of CD3 and CD8 in the observation group were significantly decreased, the ratio of CD4 / CD8 was increased, and the serum IgE was significantly increased. The difference was significant compared with the control group (P <0.01). Prompt CVA children with immune dysfunction, the pathogenesis may be the same as bronchial asthma.