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[Objective] To study the anti-inflammatory mechanism of Gentiana rigescens. [Methods] Determinations of malondialdehyde( MDA) and prostaglandin E2( PGE2),tumor necrosis factor alpha( TNF alpha) and interleukin 1 beta( IL-1 beta) content in rat chest percolate and nitric oxide( NO),PGE2,TNF alpha,beta,IL-1 and MDA content in rat lung tissue were conducted to investigate the anti-inflammatory mechanism.[Results] Compared with 5% twain- 80,ethanol extract group( 6 g / kg,crude drug amount) and water parts group( 6 g/kg,crude drug amount) of Gentiana rigescens could inhibit improvement of NO,MDA,PGE2,TNF-α and IL-1β content in chest percolate( P < 0. 01) and NO,MDA,PGE2,TNF-α and IL-1β content in lung tissue( P < 0. 01). [Conclusion]The anti-inflammatory mechanism of Gentiana rigescens may be related to the effects on generating of inflammatory mediators and antioxidant effect.
[Methods] To study the anti-inflammatory mechanism of Gentiana rigescens. [Methods] Determinations of malondialdehyde (MDA) and prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta rat chest percolate and nitric oxide (NO), PGE2, TNF alpha, beta, IL-1 and MDA content in rat lung tissue were investigated to investigate the anti-inflammatory mechanism. [Results] Compared with 5% twain- (6 g / kg, crude drug amount) of Gentiana rigescens could inhibit improvement of NO, MDA, PGE2, TNF-α and IL-1β content in chest percolate P <0.01) and NO, MDA, PGE2, TNF-α and IL-1β content in lung tissue (P <0.01). Conclusion The anti-inflammatory mechanism of Gentiana rigescens may be related to the effects on generating of inflammatory mediators and antioxidant effect.