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无胸腺小鼠(以下简称裸小鼠),系免疫缺陷动物,饲养于SPF环境中,能接受多种人类癌细胞移植。近年来我国病理学家和免疫学家用裸鼠做动物模型,在医学生物学研究中进行了大量的工作,在癌症机理研究方面取得了可喜成就,某些项目已进入国际先进行列。国内对裸鼠的需求量不断增加。过滤帽鼠盒可做为最简易的屏障用于饲养SPF动物,近年来国内外虽有这方面的介绍,但对其用来繁殖动物的安全性及使用时间的长短,未见详细报导。本文就过滤帽鼠盒性能,裸小鼠饲养繁殖的效果及微生物检测等几方面进行探讨。现将结果报告如
Athymic mice (hereinafter referred to as nude mice), immunodeficiency animals, reared in SPF environment, can accept a variety of human cancer cell transplantation. In recent years, pathologists and immunologists in our country have used nude mice as animal model, and have carried out a great deal of work in the research of medical biology. They have made gratifying achievements in the research of cancer mechanism. Some of the projects have entered the international advanced ranks. Domestic demand for nude mice continues to increase. Filtration cap mouse box can be used as the easiest barrier for keeping SPF animals, in recent years, although there is introduction in this area, but the safety of its use to breed animals and the length of time, no detailed report. This article discusses the performance of filter cap rat box, nursery mice breeding and microbial detection and other aspects. Now report the results