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人 p57基因是一个位于染色体 1 1 p1 5.5上推测的肿瘤抑制基因。p57蛋白是一种细胞周期蛋白依赖性激酶抑制物 ,对细胞增殖进行负调控。p57包含三个结构域 :一个与 CDK抑制物 p2 1 ( CIP1 )及 p2 7( KIP1 )同源的 N末端区域 ;一个中央脯氨酸富集域及一个与 p2 7相同的 C末端区 (
The human p57 gene is a putative tumor suppressor gene located on chromosome 1 1 p1 5.5. p57 protein is a cyclin-dependent kinase inhibitor that negatively regulates cell proliferation. p57 comprises three domains: an N-terminal region homologous to the CDK inhibitors p2 1 (CIP1) and p2 7 (KIP1); a central proline-rich domain and a C-terminal region identical to p2 7