[目的]考察甲氧基化反应温度和反应时间对产物收率的影响。[方法]以3-氨基-6-溴哒嗪为原料,经过氨基保护、甲氧基化和氨基脱保护等3步反应制得目标化合物。[结果]甲基化适宜的反应条件分别为反应温度65℃,反应时间2 h,产物收率85.7%。[结论]相比已有报道的以3-氨基-6-氯哒嗪为原料的高温高压法,该方法反应条件温和,原料便宜,操作便捷。 [Objective] To investigate the effect of reaction temperature and reaction time on the yield of product. [Method] 3-Amino-6-bromopyridazine was used as the starting material to prepare the title compound via three steps of amino protection, methoxylation and amino deprotection. [Result] The suitable reaction conditions of methylation were reaction temperature 65 ℃, reaction time 2 h and product yield 85.7%. [Conclusion] Compared with the reported high-temperature and high-pressure method using 3-amino-6-chloropyridazine as raw material, the method has the advantages of mild reaction conditions, cheap raw materials and convenient operation.