按照免疫遗传学的观点,子宫内胎儿是来自父母双方各一半的半异体同种移植物,应能被母体免疫系统所识别和排斥。但实际上并不发生。此提示母体可能存在防止抗胎儿排斥反应的免疫调节机制。然而,由于长期未找到母体抗胎儿排斥反应的直接证据,因而不能肯定胎儿在子宫内的存活是否与母体的免疫应答状态有关。近年来,随着生殖免疫学的迅速发展,已证实孕妇不仅能产生抗胎儿移植物排斥反应,而且也存在着防止其发生的一系列免疫调节机制。母 According to immunological genetics, the uterus fetus is a semi-allograft derived from each half of both parents and should be recognized and rejected by the maternal immune system. But it does not really happen. This suggests that there may be immunomodulatory mechanisms that prevent maternal rejection of the fetus. However, since no direct evidence of maternal anti-fetal rejection has been found for a long time, it is not certain whether the fetus’s intrauterine survival is related to the mother’s immune response status. In recent years, with the rapid development of reproductive immunology, it has been confirmed that pregnant women not only can resist the rejection of fetal graft, but also has a series of immunomodulatory mechanisms to prevent its occurrence. mother