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本文报导了工人接触铅、汞、锰职业危害的组胺代谢。共调查了177人,年龄为23～57岁,其中没有任何临床中毒症状的占30％,其它则有血管营养障碍的表现。同时还研究了对照组的组胺代谢。观察指标有血中组胺的含量,组氨酸脱羧酶(ГДК)的活性,组胺酶的活性以及血清中的结合态组胺(ГПИ)率。调查结果表明:接触铅达5年者,血中游离组胺的含量显著增加(0.039±0.0043微克/毫升),血清中组氨酸脱羧酶被激活(P<0.001),组胺酶活性被抑制(P>0.02),同时血清中结合态组胺的活性也被抑制。作者认为这在很大程度上可说明血中胺的蓄积机理。6～10年工龄组中全部指标与上述变化相类似。工龄10年以上者组胺的含量、催
This article reports the histamine metabolism of workers exposed to occupational hazards from lead, mercury and manganese. A total of 177 people were surveyed, aged from 23 to 57 years, of whom 30% did not have any clinical signs of poisoning, while others showed signs of vascular malnutrition. Histamine metabolism in the control group was also studied. Observations included histamine levels in blood, activity of histidine decarboxylase (ГДК), activity of histamine enzymes, and bound histamine (ГПИ) rates in serum. The results showed that the content of free histamine in blood increased significantly (0.039 ± 0.0043 μg / ml) and the activity of histidine decarboxylase was activated (P <0.001) in serum, and the activity of histamine enzyme was inhibited (P> 0.02), while the activity of bound histamine in serum was also inhibited. The authors consider this to a large extent the mechanism of accumulation of amines in the blood. All indicators in the 6-10 year age group were similar to the above changes. Histamine more than 10 years of histamine content, reminders