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目的 观察比较 6种眼科外用药物 ,为临床筛选较强的抑制胶原酶的眼液。方法用鼠胶原、胶原酶及考马斯亮蓝比色法来检测药物抑制胶原酶的能力。结果 6种药物有不同程度抑制胶原酶作用 ,其中卡托普利极强、乙酰半胱氨酸和依地酸钠较强 ,而枸橼酸钠、硫代硫酸钠和四环素较差。结论 0 .5 g· L- 1卡托普利眼液抑制胶原酶能力极强、副作用小、刺激性极微、药物来源及配制方便
Objective To observe and compare six kinds of ophthalmic topical drugs for the clinical screening of collagenase inhibiting eye drops. Methods Collagen, collagenase and Coomassie brilliant blue colorimetric assay were used to detect the ability of drugs to inhibit collagenase. Results The six drugs inhibited collagenase to some extent. Captopril was very strong, acetylcysteine and sodium edetate were stronger, while sodium citrate, sodium thiosulfate and tetracycline were worse. Conclusion 0 .5 g · L-1 captopril eye drops inhibit collagenase strong ability, side effects, minimal irritation, drug source and preparation convenience