论文部分内容阅读
通过肿瘤坏死因子（ＴＮＦ─α）对培养大鼠睾丸间质细胞睾酮分泌的作用及机理的研究结果表明：ＴＮＦ─α可抑制培养２４ｈ的睾丸间质细胞的睾酮分泌，对培养４８ｈ和７２ｈ的间质细胞睾酮分泌表现出双相作用，低浓度的ＴＮＦ─α可刺激睾酮分泌，高浓度的ＴＮＦ─α抑制睾酮分沁．ＴＮＦ—α与ＬＨ同时处理时，对培养２４ｈ的睾丸间质细胞，ＴＮＦ─α抑制ＬＨ刺激的睾酮分泌，对培养４８ｈ和７２ｈ的睾丸间质的细胞低浓度的ＴＨＦ—α与ＬＨ协同促进睾酮分泌，而高浓度的ＴＮＦ—α则可抑制ＬＨ刺激的睾酮分泌。高浓度的ＴＮＦ─α对睾酮的抑制作用可能是通过抑制由孕酮向睾酮的转化过程实现的。
Tumor necrosis factor (TNF-α) on cultured rat testis stromal cell secretion of testosterone and mechanism of the results showed that: TNF-α inhibited testosterone secretion of cultured testicular stromal cells 24h, cultured 48h and 72h Leydig cell testosterone secretion showed biphasic effect, low concentrations of TNF-α can stimulate testosterone secretion, high concentrations of TNF-α inhibition of testosterone Qin. When TNF-α and LH were treated at the same time, TNF-α inhibited LH-stimulated testosterone secretion in testicular stromal cells cultured for 24h. Low concentrations of THF-α and LH in cells cultured for 48h and 72h could promote testosterone Secretion, while high concentrations of TNF-α can inhibit LH-stimulated testosterone secretion. The inhibitory effect of high concentration of TNF-α on testosterone may be achieved by inhibiting the conversion of progesterone to testosterone.