In March 1992,KAP investigation and HIV blood test were carried out for 860 drug usersand 82 spouses in Ruili,Luxi,Longchuan of Yunnan Province,China. The results showed that there were 285 injecting drug users (IDUs) (33.1%) among 860 drugusers.Among 282 blood samples of IDUs,the HIV infection rate was 49.0%,highest in Ruili(81.8%,63/77),then Longchuan (44.6%,74/166),lowest in Luxi county (5.1%,2/39).Twelvenew HIV(+) were found from 75 persons,who had been tested as HIV(-) in recent two years.Sixty-two blood samples were collected among 82 spouses of IDUs with HIV(+),and 6 wereHIV(+)(9.8%),with an increase of 6.7% compared with results of the investigation twoyears ago(3.1%,2/64). In March 1992, KAP investigation and HIV blood tests were carried out for 860 drug users and 82 spouses in Ruili, Luxi, Longchuan of Yunnan Province, China. The results showed that there were 285 injecting drug users (IDUs) (33.1%) among 860 drug users.Among 282 blood samples of IDUs, the HIV infection rate was 49.0%, highest in Ruili (81.8%, 63/77), then Longchuan (44.6%, 74/166), the lowest in Luxi county (5.1% 39) .Twelvenew HIV (+) were found from 75 persons, who had been tested as HIV (-) in recent two years. Sixty-two blood samples were collected among 82 spouses of IDUs with HIV (+), and 6 were HIV +) (9.8%), with an increase of 6.7% compared with results of the investigation twoyears ago (3.1%, 2/64).