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目的:研制一种以卡波母974为基质、含有甲硝唑及盐酸林可霉素的缓释凝胶,并制定质量控制标准。方法:采用分光光度法分别对上述两种药物进行含量测定。结果与结论:甲硝唑平均回收率为99.27%、RSD为1.15%;盐酸林可霉素平均回收率为100.17%,RSD为2.22%。
OBJECTIVE: To develop a sustained-release gel containing metronidazole and lincomycin hydrochloride based on Kaposi 974 as matrix, and to develop a quality control standard. Methods: The contents of these two drugs were determined by spectrophotometry. RESULTS AND CONCLUSION: The average recovery of metronidazole was 99.27% and the RSD was 1.15%. The average recovery of lincomycin hydrochloride was 100.17% with RSD of 2.22%.