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血小板过氧化酶(PPO)表达是巨核细胞系的一个特异标志.最近研究发现在白血病和正常幼红细胞克隆形成单位的幼红细胞系中存在PPO样活性,偶尔在骨髓发育异常综合征和骨髓纤维化病人中也发现该活性,但在正常原红细胞或早熟血红蛋白化有核红细胞病人中无该活性.作者报道了1例30岁女性恶性贫血病人成熟有核红细胞中PPO样活性的检测结果.治疗前有贫血症状和下肢皮损.血清维生素B_(12)浓度为260pg/ml,Schilling实验阳性.内因子和
Platelet peroxidase (PPO) expression is a specific sign of megakaryocyte lines.Recent studies have found PPO-like activity in erythroid cells of leukemia and normal erythroid cell clonogenic units, occasionally observed in myelodysplastic syndrome and myelofibrosis This activity was also found in patients but not in normal or premature hemoglobinized erythroblasts, and the authors report the results of PPO-like activity in mature erythroblasts from a 30-year-old woman with pernicious anemia Anemia symptoms and lower extremity skin lesions.Serum vitamin B_ (12) concentration of 260pg / ml, Schilling test was positive .Internal and