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非胰岛素依赖型糖尿病（NIDDM）病人的心血管病的发生率及死亡率增多，尤其是伴有微量或明显蛋白尿的情况下更是如此。全身性的内皮机能障碍将是导致蛋白尿发展成粥样硬化的因素。以前的研究报道，血清vonWillebrand因子浓度是全身性内皮损害及血小板聚集到心血管内皮的指标，
Cardiovascular morbidity and mortality are increased in non-insulin-dependent diabetes mellitus (NIDDM) patients, especially with micro- or overt proteinuria. Systemic endothelial dysfunction will be a factor that leads to the development of albuminuria into atherosclerosis. Previous studies have reported that the serum concentration of von Willebrand factor is an indicator of systemic endothelial damage and platelet aggregation to the cardiovascular endothelium,