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为制定密闭环境空气３甲基吲哚（３ＭＩ）的最高容许浓度，进行了人体气味试验，并采用肺组织过氧化物丙二醛、脾细胞数和脾重量等指标，对雄性大鼠进行了急性和亚急性毒性参数的测定。结果为大鼠口服半数致死量为１８３０ｍｇ／ｋｇ，急性阈剂量小于１８３ｍｇ／ｋｇ，亚急性阈剂量为６１ｍｇ／ｋｇ，人体厌恶阈为０．７５ｍｇ／ｍ３。根据上述结果，结合密闭环境暴露特点和要求，论证外推密闭环境３ＭＩ的短期暴露最高容许浓度为０．５ｍｇ／ｍ３。
In order to establish the maximum allowable concentration of 3-methylindole (3MI) in closed environment, the human odor test was carried out, and the indicators of lung tissue such as malondialdehyde, spleen cell count and spleen weight were used, Rats were subjected to acute and subacute toxicological parameters. The results showed that the oral LD50 was 1830 mg / kg, the acute threshold dose was less than 183 mg / kg, the subacute threshold dose was 61 mg / kg and the human aversion threshold was 0.75 mg / m3. Based on the above results, combined with the characteristics and requirements of exposure to confined environment, it is demonstrated that the maximum allowable concentration of 3MI for the extrapolated closed environment is 0.5 mg / m3.