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西咪替丁通过与细胞色素P450的作用,而使许多凭藉混合功能氧化酶体系进行代谢的药物清除率降低。地尔硫(艹卓)(简称Dil)也能抑制有些药物在肝内的氧化代谢作用。临床资料已经证明上述两药均能影响普萘洛尔的代谢。作者研究了两药抑制普萘洛尔代谢的不同作用机制。
Cimetidine reduces the clearance of many drugs metabolized by a mixed-function oxidase system through its interaction with cytochrome P450. Diltiazem (Dilox) (Dil) also inhibits some drugs in the liver of the role of oxidative metabolism. Clinical data have proved that these two drugs can affect the metabolism of propranolol. The authors studied the different mechanisms of action of the two drugs in inhibiting the metabolism of propranolol.