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目的:探讨核电站工作者的脑血流动力学特点。方法:对2004年10月至2007年8月在我院体检的秦山核电站职工行经颅多普勒检查,记录颅内血管的各参数指标,并收集256例非核工作普通体检者作对照组,按年龄和性别分组,进行统计分析,探讨核电站工作者各参数指标和血生化指标的相关性。结果:大脑前、中、后动脉的检出率随着年龄增加而下降,在>60岁的组别里,男女间检出率差异有显著统计学意义(P<0.05)。平均血流速度(Vm)随年龄增长逐渐下降(P<0.05)。除≥50岁年龄组的大脑前、后动脉外,其余各年龄组各条颅内血管Vm男女间差异均有统计学意义(P<0.05)。搏动指数(PI)和阻力指数(RI)随年龄增长而增加(P<0.05),但各年龄组男女间的差异无统计学意义。各脑血流动力学参数与对照组相比差异无统计学意义。133例核电站职工各条颅内动脉的PI值与年龄呈正相关(P<0.05);大脑中动脉、椎动脉和基底动脉的Vm与血尿酸水平呈负相关(P<0.05)。结论:核电站工作者的脑血管动力学变化规律与正常人群相似,血尿酸水平与脑血流动力学特征相关。
Objective: To investigate the hemodynamic characteristics of nuclear power station workers. Methods: The employees of Qinshan Nuclear Power Station who were physical examinations in our hospital from October 2004 to August 2007 were examined by a Cranioptexpheric Doppler, and the parameters of intracranial blood vessels were recorded. 256 non-nuclear general examination subjects were collected as control group and Age and sex groups, statistical analysis of nuclear power plant workers to explore the various parameters and blood biochemical indicators of relevance. Results: The detection rate of anterior, middle and posterior cerebral arteries decreased with the increase of age. There was a significant difference in the detection rate between men and women in the group of> 60 years old (P <0.05). Mean blood flow velocity (Vm) decreased with age (P <0.05). Except for the anterior and posterior arteries in the age group of> 50 years old, there were significant differences in Vm between men and women in each of the other groups (P <0.05). The pulsatility index (PI) and resistance index (RI) increased with age (P <0.05), but there was no significant difference between men and women in each age group. There was no significant difference in cerebral hemodynamic parameters between the two groups. The PI value of each intracranial artery of 133 nuclear power station workers was positively correlated with age (P <0.05). The Vm of middle cerebral artery, vertebral artery and basilar artery was negatively correlated with serum uric acid level (P <0.05). CONCLUSION: The variation of cerebrovascular dynamics of nuclear power plant workers is similar to that of the normal population, and the level of serum uric acid is correlated with cerebral hemodynamics.