论文部分内容阅读
目的:研究小细胞肺癌(SCLC)的流行病学、治疗方法、院内感染的危险因素及抗菌药物的应用。方法:回顾性调查我院2002年1月–2006年12月222例SCLC患者的病例资料,并分析SCLC病例特点,合并感染危险因素及抗菌药物应用情况。结果:222例SCLC患者中,男女比例为3.6∶1,平均年龄(57.7±11.7)a,吸烟指数>400的占58.1%,局限期132例(59.5%),广泛期73例(32.9%)。222例患者中有32例未治疗(转院或放弃治疗),57例(25.7%)手术治疗,其余采用单纯化疗或放、化疗结合疗法。共53例患者发生感染82例次,感染发生率为23.9%。采用logistic分析证明反复住院、化疗是SCLC患者院内感染的危险因素。抗菌药物以头孢菌素类、氟喹诺酮类为主,应用基本合理。结论:反复住院、化疗的SCLC患者是院内感染的高发人群,应重点予以关注;在SCLC患者的感染治疗中应严格掌握适应证,控制用药量,合理使用抗菌药物。
Objective: To study the epidemiology and treatment of small cell lung cancer (SCLC), the risk factors of nosocomial infection and the application of antibacterials. Methods: The data of 222 cases of SCLC from January 2002 to December 2006 in our hospital were retrospectively analyzed. The characteristics of SCLC, the risk factors of combined infection and the application of antimicrobial agents were analyzed. Results: Among 222 SCLC patients, the ratio of male to female was 3.6:1, the average age was 57.7 ± 11.7, the smoking index was more than 400, accounting for 58.1%, the limitation period was 132 (59.5%) and the extensive period was 73 (32.9% . Of the 222 patients, 32 were untreated (transferred or surrendered), 57 (25.7%) were treated surgically and the rest were treated with chemotherapy alone or chemotherapy combined with radiotherapy. A total of 82 cases of infection occurred in 53 patients, the incidence of infection was 23.9%. Using logistic analysis to prove repeated hospitalization, chemotherapy is a risk factor for nosocomial infection in SCLC patients. Antibacterial drugs to cephalosporins, mainly fluoroquinolones, the application of basic and reasonable. CONCLUSION: Patients with recurrent hospitalization and chemotherapy of SCLC are the most frequent inpatients with nosocomial infection and should pay more attention to them. In the treatment of SCLC, the indications should be strictly controlled to control the dosage and rational use of antimicrobial agents.