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在对哈尔滨市15岁以下1型糖尿病患者进行登记的基础上,为寻找发病的环境危险因素,采用1:2的病例对照研究方法,调查了50例儿童1型糖尿病患者和100例对照。经单因素分析发现易患呼吸道感染和肠道感染、有既往麻疹和水痘病史、婴儿期(1～3个月)接触牛奶、易发热、易受惊吓以及1型糖尿病家族史均能增加发病危险。经多因素Logistic回归模型分析,筛选出易患呼吸道感染和肠道感染、既往患麻疹及易受惊吓为引起儿童1型糖尿病发病的主要危险因素。
On the basis of registering type 1 diabetic patients under 15 years of age in Harbin, 50 children with type 1 diabetes mellitus and 100 controls were investigated using a 1: 2 case-control study to find environmental risk factors for the disease. Univariate analysis revealed predisposition to respiratory and intestinal infections, previous history of measles and varicella, exposure to milk in infancy (1 to 3 months), susceptibility to fever, susceptible to start-up and family history of type 1 diabetes all increased risk of morbidity . By multivariate logistic regression analysis, the main risk factors for the onset of type 1 diabetes in children were screened for susceptible to respiratory tract infections and intestinal infections, previous measles attacks and susceptible to shock.