论文部分内容阅读
采用ELI SA法检测T2DM动脉粥样硬化病变组(A组,60例)、T2DM非动脉粥样硬化病变组(B组,66例)单纯动脉粥样硬化组(C组,62例)和正常对照组(D组,68例)血清APN水平。同时检测糖化血红蛋白(H bA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL),并计算体重指数(BMI)和胰岛素抵抗指数(HOMA-IR)。结果:APN在A组、B组、C组、D组依次减低(P<0.05);A组和B组APN水平与BMI、HOMA-IR、HbA1c呈负相关(r值分别为-0.441、-0.387、-0.176)(P<0.05),与HDL正相关(r值为0.226)(P<0.05);APN、HOMA-IR与HbA1c是DM患者动脉粥样硬化发生的独立危险因素。结论:APN是DM患者动脉粥样硬化发生的独立危险因素,有可能是治疗T2DM大血管并发症的新靶点。
ELI-SA method was used to detect atherosclerosis in T2DM group (A group, 60 cases), T2DM non-atherosclerotic lesion group (B group, 66 cases) in simple atherosclerosis group (C group, 62 cases) and normal Control group (D group, 68 cases) serum APN levels. At the same time, HbA1c, TC, TG, HDL and LDL were measured, and body mass index (BMI) and insulin resistance Index (HOMA-IR). Results: The levels of APN in groups A, B, C and D were decreased (P <0.05). The levels of APN in groups A and B were negatively correlated with BMI, HOMA - IR and HbA1c (r = -0.441, - 0.387, -0.176) (P <0.05), and positively correlated with HDL (r = 0.226) (P <0.05). APN, HOMA-IR and HbA1c were independent risk factors of atherosclerosis in DM patients. Conclusion: APN is an independent risk factor for atherosclerosis in DM patients and may be a new target for the treatment of T2DM macrovascular complications.