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目的:通过对冠心病患者血尿酸(UA)水平的检测,阐明UA与冠状动脉粥样硬化病变程度和范围的相关性。方法:行冠状动脉造影术的患者共113例,其中冠心病组64例,男51例,女13例;对照组49例,男24例,女25例。通过测定UA、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、脂蛋白a(Lpa)及血糖(Glu)水平进行2组间比较。结果:冠心病组患者TG、TC、LDL、HDL、Lpa及Glu水平与对照组比较差异无统计学意义(P>0.05),但UA水平明显高于对照组(P<0.05);UA水平与冠状动脉狭窄程度呈正相关(r=0.53,P<0.05)。结论:UA水平与冠状动脉病变程度和范围呈正相关。
Objective: To investigate the relationship between UA and the degree and extent of coronary atherosclerosis by detecting the level of uric acid (UA) in patients with coronary heart disease. Methods: A total of 113 patients underwent coronary angiography, including 64 coronary heart disease patients, 51 males and 13 females; control group of 49 patients, 24 males and 25 females. The levels of UA, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein (Lpa) and glucose (Glu) . Results: The levels of TG, TC, LDL, HDL, Lpa and Glu in coronary heart disease group were not significantly different from those in control group (P> 0.05), but UA level was significantly higher than that in control group (P <0.05) Coronary stenosis was positively correlated (r = 0.53, P <0.05). Conclusion: The level of UA is positively correlated with the severity and extent of coronary artery disease.