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探讨前哨淋巴结活检 (SLNB)在乳腺癌临床中的应用价值。使用放射性99mTc -亚锡大分子右旋糖酐对 2 1例女性乳腺癌患者的前哨淋巴结 (SLN )进行定位及活检。检出SLN 18例 ( 85 .7% )。SLN检出成功率与肿瘤所在部位、病理类型、病理分期无关 (P >0 .0 5 )。共取出 3 3个SLN ,其中 1个者 9例 ( 5 0 .0 % ) ,2个者 5例 ( 2 7.8% ) ,3个者 2例 ( 11.1% ) ,4个者 2例 ( 11.1% )。 11例SLN阳性者 ,10例腋淋巴结 (ALN )呈阳性 ,1例ALN呈阴性。 7例SLN阴性者 ,1例ALN呈阳性 ,6例ALN阴性。灵敏度 91.7% ,特异度 10 0 % ,准确性 88.9% ,假阴性率 8.3 %。提示99mTc -亚锡大分子右旋糖酐皮下注射、放射性核素淋巴显像定位行SLNB可反映腋淋巴结转移情况。
To investigate the clinical value of sentinel lymph node biopsy (SLNB) in breast cancer. Sentinel lymph nodes (SLNs) were localized and biopsied in 21 female breast cancer patients using radioactive 99mTc-stannous macromolecular dextran. 18 cases of SLN were detected (85.7%). The success rate of SLN detection was not related to tumor location, pathological type and pathological stage (P> 0.05). A total of 33 SLNs were obtained. Among them, 9 (50.0%) were found in 1 patient, 5 patients (2 7.8%) in 2 patients, 2 patients (11.1%) in 3 patients and 2 patients (11.1% ). Eleven SLN-positive cases showed positive axillary lymph node (ALN) in 10 cases and negative ALN in 1 case. Seven cases of SLN negative, one case of ALN positive, six cases of ALN negative. Sensitivity 91.7%, specificity 10 0%, accuracy 88.9%, false negative rate of 8.3%. Tip 99mTc - stannous macromolecular dextran subcutaneous injection, radionuclide lymphoscintigraphy SLNB line can reflect the axillary lymph node metastasis.