论文部分内容阅读
Objective To investigate the action of recombinantprotein of tissue inhibitor of metalloproteinase-3 (TIMP-3) on apoptosis of MC3T3-E1 osteoblasts. Methods Cell survival rate and apoptosis were measured by MTT and ELISA respectively. The expressions of Fas, FasL, Bel-2, Bax, caspase-3 , caspase-8, cytochrome c and phosphorylations of JNK, p38 and extracellular signalregulated kinase (ERK) 1/2 were analysed by Western blotting. Results TIMP-3 reduced survival rate of MC3T3-E1 cells and promoted apoptosis of MC3T3-E1
Objective To investigate the action of recombinant protein of tissue inhibitor of metalloproteinase-3 (TIMP-3) on apoptosis of MC3T3-E1 osteoblasts. Methods Cell survival rate and apoptosis were measured by MTT and ELISA respectively. The expressions of Fas, FasL, Bel- 2, Bax, caspase-3, caspase-8, cytochrome c and phosphorylations of JNK, p38 and extracellular signalregulated kinase (ERK) 1/2 were analyzed by Western blotting. Results TIMP-3 reduced survival rate of MC3T3- apoptosis of MC3T3-E1