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目的现场观察氯硝柳胺乙醇胺盐喷雾剂预防耕牛日本血吸虫感染的效果,为实施以传染源控制为主的血吸虫病综合防治策略提供技术支撑。方法以血吸虫病流行区江西省永修县吴城镇160头耕牛为实验对象,对实验耕牛逐一编号,收集牛粪采用顶管孵化法检查耕牛血吸虫感染情况。在给予吡喹酮治疗后,全部粪检阴性实验耕牛随机分成A、B、C 3组:A组每隔15 d采用氯硝柳胺乙醇胺盐喷雾剂对耕牛全身喷药1次,剂量为每次500 ml/头;B组每隔30 d采用氯硝柳胺乙醇胺盐喷雾剂对耕牛全身喷药1次;C组为对照组,每隔15 d采用不含氯硝柳胺乙醇胺盐的空白剂对耕牛喷药1次。试验期间,每隔30 d采用顶管孵化法检查全部试验耕牛血吸虫感染情况。结果持续喷药90 d后,喷药组A、B及对照组耕牛血吸虫病患病率分别为4.00%、4.08%和24.49%;与对照组相比,喷药组A和喷药组B耕牛血吸虫病患病率分别下降83.67%和83.34%。结论采用氯硝柳胺乙醇胺盐喷雾剂对耕牛进行全身喷药可预防耕牛感染日本血吸虫,降低耕牛血吸虫病患病率。
Objective To observe the effect of niclosamide ethanolamine salt spray on the prevention of Schistosoma japonicum infection in the field and provide technical support for the implementation of the integrated control strategy of schistosomiasis controlled by infection source. Methods In the endemic area of schistosomiasis, 160 cattle breeds in Wucheng Town, Yongxiu County, Jiangxi Province were used as experimental objects. The experimental cattle were numbered one by one, and cow dung was collected to investigate the infection status of cattle with schistosomula. After the praziquantel treatment, all the fecal negative test cattle were randomly divided into A, B, C 3 groups: A group every 15 days with niclosamide ethanolamine spray spray the whole body of cattle once, the dose For each 500 ml / head; Group B every 30 d with niclosamide ethanolamine spray spraying the whole body of cattle once; C group as the control group, every 15 d without niclosamide ethanolamine Salt blank agent on the cattle spraying 1 times. During the test, all experimental cows were infected with Schistosoma japonicum by pipette incubation every 30 days. Results The prevalence rates of bovine schistosomiasis in vaccinated group A, B and control group were 4.00%, 4.08% and 24.49%, respectively, after 90 days of continuous spraying. Compared with control group, spraying group A and B The prevalence of cattle schistosomiasis decreased by 83.67% and 83.34% respectively. Conclusion The systemic injection of oxaliplatin ethanolamine salt spray to the cattle can prevent the infection of Schistosoma japonicum by cattle and reduce the prevalence of schistosomiasis in cattle.