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目的观察银杏达莫注射液联合前列地尔治疗后循环缺血性眩晕的临床疗效。方法 74例后循环缺血性眩晕患者随机分为两组,每组37例。治疗组采用银杏达莫注射液联合前列地尔治疗,对照组仅采用前列地尔治疗。两组疗程均为10-14d。比较两组疗效、颅多普勒超声血流速度、血液流变学指标水平及不良反应发生情况。结果治疗组总有效率显著高于对照组(P<0.05);两组椎动脉和基底动脉收缩期末峰流速、舒张期末峰流速治疗后较治疗前显著增加(P<0.05);治疗组椎动脉和基底动脉收缩期末峰流速、舒张期末峰流速治疗后显著高于对照组(P<0.05);两组全血高切黏度、血浆粘度、纤维蛋白原治疗后较治疗前显著减少(P<0.05);治疗组全血高切黏度、血浆粘度、纤维蛋白原治疗后显著低于对照组(P<0.05);治疗期间均未见明显不良反应。结论银杏达莫注射液联合前列地尔治疗后循环缺血性眩晕的临床疗效显著,安全可靠,具有重要研究价值。
Objective To observe the clinical efficacy of gingko Damo injection combined with alprostadil for treatment of ischemic vertigo. Methods 74 patients with posterior circulation ischemic vertigo were randomly divided into two groups, 37 cases in each group. The treatment group with gingko Damo injection combined with alprostadil, the control group only treated with alprostadil. The two groups of treatment are 10-14d. The curative effect of the two groups were compared, and the C Doppler ultrasound blood flow velocity, hemorheology index and adverse reactions were compared. Results The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). The peak systolic and peak diastolic velocity of the vertebral artery and the basilar artery increased significantly in both groups (P <0.05) (P <0.05). Compared with the control group, the peak flow velocity at the end of systole and the peak velocity at the end diastole of the basilar artery were significantly higher than those of the control group (P <0.05). The high blood viscosity, plasma viscosity and fibrinogen were significantly decreased ). In the treatment group, the whole blood high shear viscosity, plasma viscosity and fibrinogen were significantly lower than those in the control group (P <0.05). No obvious adverse reactions were observed during the treatment. Conclusion The clinical efficacy of ginkgo dipyridamole injection combined with alprostadil after treatment of ischemic vertigo is significant, safe and reliable, and has important research value.