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据Huang FK 2015年6月17日(Nature Commu,2015,6:7465-7465.)报道,美国华人科学家利用高通量筛选的方法发现了一些小分子能够特异性靶向参与肌动蛋白组装的关键蛋白——Fascin,同时证明抑制Fascin的活性能够阻断丝状伪足形成,抑制肿瘤的迁移和侵袭。肿瘤转移的一个关键步骤是肿瘤细胞的迁移和侵袭,这一过程的实现需要细胞内细胞骨架蛋白的重新排列。丝状伪足是参与
According to Huang FK, June 17, 2015 (Nature Commu, 2015, 6: 7465-7465.), Chinese scientists using high-throughput screening found that small molecules can specifically target actin assembly The key protein, Fascin, also demonstrated that inhibition of Fascin activity blocked the formation of filopodia and inhibited tumor migration and invasion. A key step in tumor metastasis is the migration and invasion of tumor cells. The realization of this process requires the rearrangement of intracellular cytoskeletal proteins. Fillet pseudopods are involved