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本品为醛糖还原酶抑制剂,是抗糖尿病症状的药物。多元醇途径中有两种酶,即醛糖还原酶和山梨醇脱氢酶,这两种酶催化以下反应: 葡萄糖山梨醇果糖在此途径第一步醛糖还原酶利用辅因子NADPH,使葡萄糖醛式还原成相应的葡萄糖醇式,山梨醇。第二步中山梨醇脱氢酶利用NAD~+使山梨醇氧化成果糖。山梨醇途径首先发现于精囊,以后在多种组织也有发现。 1959年在糖尿病鼠的晶状体中发现有山梨醇,这表明醛糖还原酶在晶状体中也有
This product is aldose reductase inhibitors, anti-diabetic symptoms of drugs. There are two enzymes in the polyol pathway, aldose reductase and sorbitol dehydrogenase, which catalyze the following reactions: Glucose Sorbitol The first step in this pathway Aldose reductase utilizes the cofactor NADPH, which causes glucose The aldehyde is reduced to the corresponding glucitol, sorbitol. In the second step sorbitol dehydrogenase utilizes NAD ~ + to oxidize sorbitol to fructose. The sorbitol pathway was first found in seminal vesicles and later in many tissues. Sorbitol was found in the lens of diabetic rats in 1959, suggesting that aldose reductase is also present in the lens