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目的:评价输精管结扎术与前列腺癌发病风险的关系。方法:以“前列腺癌”、“输精管结扎术”及其同义、近义词为关键词,在CBMDisc、CMCC、CMAC、CNKI(1978年至2009年1月6日)和PubMed(1965年至2009年1月6日)等国内外数据库上进行全面检索,按文献纳入及剔除标准筛选出符合要求的文献,提取出相关数据,以RevMan4.2进行一致性检验后采取随机效应模型对纳入研究的文献进行综合定量分析,求出合并OR值及95%CI,并分层分析结扎年限<20年和≥20年与前列腺癌发病风险的OR值及95%CI。结果:共有27篇文献纳入研究,其中队列研究7篇,病例对照研究20篇,共收集研究对象252594例,其中病例20088例,对照232506例。合并OR值(95%CI)为1.10(0.97～1.24),分层分析显示结扎年限<20年和≥20年的合并OR值(95%CI)分别为0.94(0.83～1.06)和1.05(0.90～1.23)。结论:现有研究表明输精管结扎术不会增加前列腺癌的发病风险。
Objective: To evaluate the relationship between vasectomy and the risk of prostate cancer. METHODS: The key words of “prostate cancer”, “vasectomy” and its synonyms and synonyms were selected as keywords in CBMDisc, CMCC, CMAC, CNKI (1978 to January 6, 2009) and PubMed Year to January 6, 2009) and other databases at home and abroad to conduct a comprehensive search, according to the inclusion of the literature and remove the standard screening out the documents that meet the requirements, extract the relevant data to RevMan4.2 consistency test to take a random effect model The data included in the study were used for comprehensive quantitative analysis. The combined odds ratio (OR) and 95% CI were calculated. The OR and 95% CI of the risk of prostate cancer with a ligation duration of <20 years and ≥20 years were analyzed by stratified analysis. Results: A total of 27 articles were included in the study, including 7 cohort studies and 20 case-control studies. A total of 252594 subjects were collected, of which 20088 cases and 232506 controls. The combined OR (95% CI) was 1.10 (0.97-1.24). Stratified analysis showed that the combined odds ratio (95% CI) of the ligation years <20 years and ≥20 years were 0.94 (0.83-1.06) and 1.05 ~ 1.23). Conclusions: Current research shows that vasectomy does not increase the risk of prostate cancer.