Integration of soil information system (SIS) and interactive self-organizing data (ISODATA) was studied to establish proper agricultural developing zones in red soil region of southern China which are of crucial importance to farmers, researchers, and decision makers while utilizing and managing red soil resources. SIS created by using ARC/INPO was used to provide data acquisition, systematic model parameter assignment, and visual display of analytic results. Topography, temperature, soil component (e.g., organic matter and pH) and condition of agricultural production were selected as parameters of ISODATA model. Taking Longyou County, Zhejiang Province as the case study area, the effect of the integration and recommendations are discussed for future research. Integration of soil information system (SIS) and interactive self-organizing data (ISODATA) was studied to establish proper agricultural developing zones in red soil region of southern China which are crucial importance to farmers, researchers, and decision-makers while utilizing and managing red soil resources. SIS created by using ARC / INPO was used to provide data acquisition, systematic model parameter assignment, and visual display of analytic results. Topography, temperature, soil component (eg, organic matter and pH) and condition of agricultural production were selected Taking parameters of ISODATA model. Taking Longyou County, Zhejiang Province as the case study area, the effect of the integration and recommendations are discussed for future research.