[Objective] To figure out the dosage range of Tripterygium wilfordii tablets,Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii when used to treat inflammation. And their effects were compared and their mechanism of anti-inflammation was explored. It’s expected that the study could provide reference basis for clinical medication. [Methods]Different dose of Tripterygium wilfordii tablets,Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii were administrated to mice by intragastric administration. The ED50 of drugs used to treat acute inflammation was calculated by ear swelling model in mice induced by mixture of compound croton oil. After the last delivery,the content changes of PGE2,TNF-α and IL-2 in mice blood were detected. The effect of Tripterygium wilfordii tablets,Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii on acue inflammation in mice was explored. [Results] The median effective dose ED50 of Tripterygium wilfordii tablets and Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii when used to treat ear swelling in mice induced by mixture of compound croton oil were 17. 753 μg / kg,9. 235 7 mg / kg and0. 370 g / kg. When the median effective dose was presented by the dose of triptolide,then they reached 17. 753 μg / kg,8. 922 μg / kg and5. 667 μg / kg. It’s 20. 30,10. 21 and 6. 48 times of the daily dosage of patient at the weight of 70 kg in clinic. The content of PGE2,TNF-αand IL-2 in mice blood of various medication groups were reduced significantly( P < 0. 05) and it displayed a good dose-effect relationship.[Conclusions]Tripterygium wilfordii tablets,Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii could treat acute inflammation in mice induced by mixture of compound croton oil. And the strength in order were Water Decoction of Tripterygium wilfordii > Tripterygium wilfordii polyglycoside > Tripterygium wilfordii tablets. It indicated that triptolide had a good anti-inflammatory effect on acute inflammation and its effect showed a good dose-effect relationship. But it’s not the only material base that had anti-inflammatory effect in Tripterygium wilfordii. Inhibiting the production and release of inflammatory factor PGE2,TNF-α and IL-2 was one of the mechanism of Tripterygium wilfordii tablets,Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii which played a role in anti-inflammation. And Objectives To figure out the dosage range of Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii when used to treat inflammation. And their effects were compared and their mechanism of anti-inflammation was explored. It’s expected that the study could could [Methods] Different dose of Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii were administered to mice by intragastric administration. The ED50 of drugs used to treat acute inflammation was calculated by ear swelling model in The effect of Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii on acue inflammation in mice was explored. [Results] The median effectiv e dose ED50 of Tripterygium wilfordii tablets and Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii when used to treat ear swelling in mice induced by mixture of compound croton oil were 17. 753 μg / kg, 9. 235 7 mg / kg and 0. 370 g / kg. When the median effective dose was presented by the dose of triptolide, then they reached 17. 753 μg / kg, 8.922 μg / kg and 5. 667 μg / kg. It’s 20. 30, 10. 21 and 6 . 48 times of the daily dosage of patient at the weight of 70 kg in clinic. The content of PGE2, TNF-αand IL-2 in mice blood of various doses were reduced significantly (P <0.05) and it displayed a Good dose-effect relationship. [Conclusions] Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii could treat acute inflammation in mice induced by mixture of compound croton oil. And the strength in order were Water Decoction of Tripterygium wilfordii> Tripterygium wilfordii polyglycoside > TriIt showed that triptolide had a good anti-inflammatory effect on acute inflammation and its effect showed a good dose-effect relationship. But it’s not the only material base that had anti-inflammatory effect in Tripterygium wilfordii. Inhibiting the production and release of inflammatory factor PGE2, TNF-α and IL-2 was one of the mechanisms of Tripterygium wilfordii tablets, Tripterygium wilfordii polyglycoside and Water Decoction of Tripterygium wilfordii that which plays a role in anti-inflammation.