我院对于复方炔雌醚的药理作用和毒性试验研究过去曾有过报道。本文主要报告复方炔雌醚在狗和小鼠的长期安全性试验结果。 (一)狗慢性毒性试验: 1.动物用体重20～30公斤的成年雌性狼狗,分成4组(每组动物3～4只)。(1)对照组;(2)单方炔雌醚:每次口服炔雌醚5片(每片含3毫克),按体重计约相当于临床剂量的10～12.5倍;(3)复方炔雌醚(小剂量);每次口服复方炔雌醚1片,(每片含炔雌醚 Pharmacological effects and toxicological tests of compound ethinyl estradiol in our hospital have been reported in the past. This article reports the long-term safety trials of compound ethinyl estradiol in dogs and mice. (A) chronic toxicity test of dogs: 1. Animals Adult female dogs weighing 20 to 30 kg were divided into 4 groups (3 to 4 animals per group). (1) control group; (2) mononuclear ethinyl estradiol: 5 tablets of acetylene and estradiol (3 mg per tablet), equivalent to about 10 to 12.5 times of clinical dose by weight; (3) Ether (small dose); each time oral compound ethinyl estrone 1, (each containing ethinylestradiol