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目的：探讨蓝斑复合核在呼吸调节中的作用及机制。方法：本实验采用脑内核团微量注射的方法，实验在２７只麻醉、制动、切断双侧颈迷走神经和人工通气的家兔上进行。结果：在家兔蓝斑复合核微量注入利多卡因２０μｇ／μｌ，呼吸频率和膈神经放电频率减慢，动脉血压无明显变化。于延髓孤束核区预注射α２－受体阻断剂育亨宾４μｇ／μｌ，可明显拮抗利多卡因阻滞蓝斑复合核区的呼吸抑制效应。结论：蓝斑复合核参与呼吸调节，此作用可能部分通过延髓孤束核区的α２受体介导。
Objective: To investigate the role and mechanism of locus coeruleus in respiratory regulation. Methods: In this experiment, intracranial microinjection of nuclei was used. The experiment was performed on 27 anesthetized, braked and severed bilateral vagus nerve and artificial ventilation rabbits. Results: The injection of lidocaine 20μg / μl into the locus coeruleus of rabbits showed a slight decrease in respiratory rate and phrenic nerve discharge frequency, but no significant change in arterial pressure. Preincubation of α2-blocker yohimbine 4μg / μl in the medulla oblongata solitary nucleus could significantly inhibit the respiratory depression effect of the block locus coeruleus in lidocaine. CONCLUSION: The locus coeruleus participates in respiratory regulation, which may be partly mediated by α2 receptors in medulla oblongata nucleus.