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发现 5 咪唑甲醛 (1)与γ 溴代巴豆酸酯 (2 )在弱碱条件下首先进行亲核取代反应生成 3,继而生成γ 碳负离子并转移到α 位 ,然后进行分子内亲核进攻成环、脱水生成 4的串联反应 .提供了一个合成咪唑并 [1,5 a]吡啶 7 羧酸酯衍生物的新方法
It was found that 5-imidazole carboxaldehyde (1) and γ-bromocrotonate (2) were first subjected to nucleophilic substitution reaction under weakly alkaline conditions to generate 3, and then γ-carbanion was generated and transferred to α-position, followed by intramolecular nucleophilic attack The ring, dehydration, generates a series reaction of 4. A new method for the synthesis of imidazo [1,5 a] pyridine 7 carboxylate derivatives is provided