论文部分内容阅读
上皮—间充质转化(EMT)描述的是上皮细胞在外界因素的作用下,获得某些间充质细胞特征(如极性丧失、细胞骨架蛋白的改变和成纤维细胞样外形等)的现象,其在许多生理和病理过程中都具有重要的作用。学者们近年来对EMT生物学作用的研究主要围绕胚胎发育、损伤修复、脏器纤维化以及癌症的发生和发展等几个方面展开。因此,本文拟从上述几个方面对EMT的生物学作用作一综述,以期为某些疾病的诊断和治疗提供新的视点和思路。
Epithelial-mesenchymal transition (EMT) describes the phenomenon that epithelial cells acquire characteristics of certain mesenchymal cells (such as loss of polarity, changes in cytoskeletal proteins, and fibroblast-like appearance, etc.) under the influence of external factors , Which plays an important role in many physiological and pathological processes. Researchers in recent years, the role of EMT in the study focused on embryonic development, injury repair, organ fibrosis and the occurrence and development of cancer and so on. Therefore, this article intends to summarize the biological effects of EMT from the above aspects in order to provide new perspectives and ideas for the diagnosis and treatment of certain diseases.