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目的探讨尼尔雌醇与奥硝唑栓联合用药治疗老年性阴道炎的效果。方法治疗组46例每晚睡前将1粒奥硝唑栓塞入阴道连用7d,同时口服尼尔雌醇1mg,1次/周。对照组22例单用奥硝唑栓1粒每晚塞入阴道连用7d。结果治疗组治愈率95.65%,有效率100%。对照组治愈率63.6%,总有效率86.4%。随访3月治疗组复发率2.2%,对照组复发率26.3%。两组比较差异有统计学意义(P<0.05)。结论尼尔雌醇与奥硝唑栓联合阴道用药增强阴道抵抗力,抑制细菌生长,见效快,同时口服尼尔雌醇能长时间维持体内雌激素水平,持续增强阴道抗炎能力,防止复发。
Objective To investigate the effect of combination of nilestriol and ornidazole in the treatment of senile vaginitis. Methods 46 cases were treated with ornithiazole embolization into the vagina for 7 days before going to bed at night. At the same time, oral administration of nilestriol 1 mg once a week. Control group, 22 cases of single ornidazole suppository plug into the vagina every night for 7 days. Results The cure rate of the treatment group was 95.65%, the effective rate was 100%. Control group, the cure rate was 63.6%, the total efficiency of 86.4%. Follow-up March treatment group recurrence rate of 2.2%, control group recurrence rate of 26.3%. The difference between the two groups was statistically significant (P <0.05). Conclusion Nilestriol and ornidazole suppository combined with vaginal administration can enhance vaginal resistance, inhibit bacterial growth and achieve rapid response. In addition, oral administration of nylestriol can maintain estrogen levels for a long time and enhance vaginal anti-inflammatory ability to prevent recurrence.