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慢性丙型肝炎是严重的全球性卫生问题,其进展为肝硬化、肝癌的几率较高,目前缺乏新的、有效的、不良反应小的治疗手段。水飞蓟素是广泛应用于多类肝病的常用药物,其主要作用包括具有抗氧化、抗纤维化、抗炎、免疫调节以及促肝细胞再生作用。目前研究发现水飞蓟素具有抗丙型肝炎病毒的作用,其主要作用机制为直接抑制丙型肝炎病毒的作用及间接由NF-κB介导的抗炎、调节免疫作用。临床观察发现水飞蓟素静脉制剂其可以降低HCV-RNA水平,并可辅助增强干扰素抗病毒作用,但其是否可有效抗丙型肝炎病毒仍需大样本临床试验证实。
Chronic hepatitis C is a serious global health problem, and its progress to cirrhosis, liver cancer is higher, the current lack of new, effective, small adverse reactions to treatment. Silymarin is widely used in a variety of liver diseases commonly used drugs, its main role includes anti-oxidation, anti-fibrosis, anti-inflammatory, immune regulation and promote liver regeneration. The current study found that silymarin has anti-hepatitis C virus effect, the main mechanism of action for the direct inhibition of the role of hepatitis C virus and indirectly mediated by NF-κB anti-inflammatory and immunomodulatory effects. Clinically observed that intravenous silymarin preparations can reduce the level of HCV-RNA, and can help enhance the antiviral effect of interferon, but whether it is effective against hepatitis C virus still need a large sample of clinical trials confirmed.