患者 ,女 ,46岁。 1996年 8月因右手小拇指尖处发现黄豆大小黑色素瘤 ,行第二、三指节切除术 ;1999年 2月左肩部及左肋下发现青黑色高出皮肤斑块 ,随行大于病灶切除术 ;1999年 4月因右腋窝和左乳房左上线处分别发现 10ｃｍ× 7ｃｍ和 3 5ｃｍ× 3 .5ｃｍ黑色素瘤样改变 ,第三 Patient, female, 46 years old. In August 1996, the second and third knuckles were removed due to the presence of soy-sized melanoma at the tip of the right-handed little finger. In February 1999, the black-black skin plaque was found on the left shoulder and left ribs, and the enrollment was greater than the lesion resection. In April 1999, 10cm x 7cm and 35cm x 3.5cm melanoma-like changes were found in the right axillary and left breast top left line, respectively.