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目的：利用自行建立的条件性位置偏爱模型，探讨Ｎ－硝基－Ｌ－精氨酸（ＮＯ２Ａｒｇ）对阿片类物质诱导的精神依赖性的影响。方法：通过观察吗啡、二氢埃托啡精神依赖的昆明种小鼠，在皮下注射ＮＯ２Ａｒｇ前后于条件性位置偏爱箱偏爱侧停留的时间，判断小鼠精神依赖情况。结果：４ｍｇ／ｋｇＮＯ２Ａｒｇ使吗啡和二氢埃托啡精神依赖小鼠在偏爱侧停留时间分别由给予ＮＯ２Ａｒｇ前的（６．０９±２．０２），（７．９８±０．７２）ｍｉｎ增加到给予后的（９．３１±１．１０），（９．４８±１．２１）ｍｉｎ（Ｐ＜０．０１）。结论：ＮＯ２Ａｒｇ可逆转吗啡和二氢埃托啡所致的条件性位置偏爱，提示ＮＯ在阿片类药物精神依赖性形成中起重要作用。
OBJECTIVE: To investigate the effect of N-nitro-L-arginine (NO2Arg) on the psychic dependence induced by opioids by using a self-made conditional place preference model. Methods: By observing morphine and dihydroetorphine-dependent Kunming mice, the dependence of mice on mood preference was judged by the time spent on subjective injection of NO2Arg in preference position side of preference box. RESULTS: Compared with pretreatment with NO2Arg (6.09 ± 2.02) and (7.98 ± 0.72) min before and after administration of NO2Arg, morphine and dihydroetorphine-dependent mice at 4 mg / kg NO2Arg increased (9.31 ± 1.10) and (9.48 ± 1.21) min after administration (P <0.01). CONCLUSION: NO2Arg reverses the conditioned place preference induced by morphine and dihydroetorphine, suggesting that NO plays an important role in the formation of psychosocial dependence of opioids.