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用C_(57)BL/3J小鼠29只,分成运动组(12只),对照组(12只)和青年组(5只)三组.运动组从第6个月起隔天跑转笼2小时,对照组不跑转笼.当这两组小鼠死亡总数达50%时(经过16个月零8天),将两组余下的小鼠(22月龄)全部杀死,取出脊髓腰膨大(L_2)与青年组(6月龄)的相比较.结果表明:运动组与对照组的存活率无显著性差异,P>0.05;老年的小鼠脊髓前角神经元总数比青年组的少,但运动组神经元减少较轻,P<0.05,减少的主要的是小神经元,大、中神经元并没有减少;而对照组神经元减少明显,P<0.01,减少的主要是大、中神经元.在三组随机抽出的大神经元胞体切面面积中,运动组最大,青年组居中,对照组最小,两两比较P均<0.01.实验结果提示:长期适量的运动对小鼠的寿命影响不大,但可能会减轻脊髓前角神经元在衰老过程中的死亡程度,最明显的影响是将运动神经元保存下来.
29 C57BL / 3J mice were divided into three groups: exercise group (n = 12), control group (n = 12) and youth group (n = 5) Two hours later, the control group did not run in. When the total number of deaths in both groups reached 50% (after 16 months and 8 days), the remaining two groups of mice (22 months old) were killed and the spinal cord was removed The results showed that there was no significant difference in the survival rate between the exercise group and the control group (P> 0.05), and the total number of neurons in the spinal cord anterior horn in the aged mice was higher than that in the youth group , But the motor neurons decreased less, P <0.05, the main decrease was small neurons, large and medium neurons did not decrease; while the control group neurons decreased significantly, P <0.01, the decrease was mainly Large and medium neurons in the three groups of large neuronal cell body section area extraction, the largest movement group, young middle group, the control group the smallest, any comparison P <0.01.Experimental results suggest that: long-term moderate exercise on the small Rat life has little effect, but may reduce neuronal anterior horn angle in the process of aging, the most obvious impact is to save motor neurons.